Mitochondria cannot be made de novo but replicate by a mechanism of recruitment of new
proteins, which are added to preexisting subcompartments. Although mitochondria have …

In creating mitochondria some 2 billion years ago, the first eukaryotes needed to establish
protein import machinery in the membranes of what was a bacterial endosymbiont. Some of …

Age‐related loss of muscle mass and strength (sarcopenia) leads to a decline in physical
function and frailty in the elderly. Among the many proposed underlying causes of …

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs)
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …

The translocase of the outer mitochondrial membrane (TOM) complex is the main entry gate
for mitochondrial precursor proteins synthesized on cytosolic ribosomes. Here we report the …

Although a direct causative pathway from the gene mutation to the selective neostriatal
neurodegeneration remains unclear in Huntington's disease (HD), one putative pathological …

The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly
replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD) …

The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the
oxidative phosphorylation complex machinery most notably on the crista membranes …

Although Alzheimer's disease (AD) is the most common neurodegenerative disease, the
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …

Mitochondrial dysfunction is associated with neuronal loss in Huntington's disease (HD), a
neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin …