The organization of metabolic multienzyme complexes has been hypothesized to benefit
metabolic processes and provide a coordinated way for the cell to regulate metabolism …

Roughly a third of the world's population is estimated to have latent Mycobacterium
tuberculosis infection, being at risk of developing active tuberculosis (TB) during their …

Chorismate and isochorismate represent an important branching point connecting primary
and secondary metabolism in bacteria, fungi, archaea and plants. Chorismate-and …

Bacteria have acquired sophisticated mechanisms for assembling and disassembling
polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α …

A large section of cellular proteins in both prokaryotic and eukaryotic systems have
oligomeric property. Intently, oligomerization of protein is an invaluable phenomenon from …

Corynebacterium glutamicum is widely used for the industrial production of amino acids,
nucleotides, and vitamins. The shikimate pathway enzymes DAHP synthase (CgDS …

DAHP synthase and chorismate mutase catalyze key steps in the shikimate biosynthetic
pathway en route to aromatic amino acids. In Mycobacterium tuberculosis, chorismate …

Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM)
has only low activity on its own. Remarkably, its catalytic efficiency k cat/K m can be boosted …

Our ability to engineer protein structure and function has grown dramatically over recent
years. Perhaps the next level in protein design is to develop proteins whose function can be …

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway,
is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants …