Purpose To understand why some patients respond to immunotherapy but many do not, a
clear picture of the tumor microenvironment (TME) of head and neck squamous cell …

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been
demonstrated to be of prognostic value in various cancers. In this systematic review and …

Head and neck squamous cell carcinomas (HNSCC) are associated with significant
treatment-related morbidity and poor disease-free and disease-specific survival, especially …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type,
has often an aggressive course and is poorly responsive to current therapeutic approaches …

Immunotherapy revolutionized cancer treatment but has yet to elicit durable responses in the
majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is …

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and
recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We …

Cancer is one of the leading causes of death in the world, which is the second after heart
diseases. Adenoviruses (Ads) have become the promise of new therapeutic strategy for …

Background Recurrent laryngeal squamous cell carcinomas (LSCCs) are associated with
poor outcomes, without reliable biomarkers to identify patients who may benefit from …

Background: Oral squamous cell carcinoma (OSCC) is the most common cancer of oral and
maxillofacial region. A recent clinical research has shown that tumor immune …

Head and neck tumors (HNCs) are a common tumor in otorhinolaryngology head and neck
surgery, accounting for 5% of all malignant tumors in the body and are the sixth most …