Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

Biomimetic polymers and materials have been widely used in tissue engineering for
regeneration and replication of diverse types of both normal and diseased tissues. Cancer …

Cells cultured within a three-dimensional (3D) in vitro environment have the ability to
acquire phenotypes and respond to stimuli analogous to in vivo biological systems. This …

Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …

Maintenance of cancer stem cells (CSCs) is regulated by the tumor microenvironment.
Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to …

Common models used in breast cancer studies, including two-dimensional (2D) cultures
and animal models, do not precisely model all aspects of breast tumors. These models do …

Background: The lack of a stable source of hepatocytes is one of major limitations in
hepatocyte transplantation and clinical applications of a bioartificial liver. Human embryonic …

Purpose. To probe growth characteristics of human umbilical cord mesenchymal stem cells
(hUCMSCs) cultured with alginate gel scaffolds, and to explore feasibility of wound dressing …

Mesenchymal stem cells (MSCs), such as adipose-derived stem cells (ADSCs), have the
most impressive ability to reduce inflammation through paracrine growth factors and …

Epithelial-adipose interaction is an integral step in breast cancer cell invasion and
progression towards lethal metastatic disease. Understanding the physiological contribution …