The problem of antimalarial resistance and its implications for drug discovery
TM Schäfer, L Pessanha de Carvalho… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Malaria remains a devastating infectious disease with hundreds of thousands of
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …
A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line
treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported …
treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported …
Determinants of piperaquine-resistant malaria in South America
Malaria has seen a worrying resurgence across tropical regions, with cases and mortality
rising after a 15-year decline earlier this century. The major impact falls on sub-Saharan …
rising after a 15-year decline earlier this century. The major impact falls on sub-Saharan …
Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin
AF Goncalves, A Lima-Pinheiro, M Teixeira… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Malaria parasites increasingly develop resistance to all drugs available in the
market, hampering the goal of reducing malaria burden. Methods Herein, we evaluated the …
market, hampering the goal of reducing malaria burden. Methods Herein, we evaluated the …
The spread of a validated molecular marker of artemisinin partial resistance pfkelch13 R622I and association with pfhrp2/3 deletions in Eritrea
S Mihreteab, K Anderson, I Molina-de la Fuente… - medRxiv, 2023 - medrxiv.org
Eritrea was the first African country to switch away from exclusive use of HRP2-based RDTs
for the detection of P. falciparum due to high prevalence of pfhrp2/3-deleted P. falciparum …
for the detection of P. falciparum due to high prevalence of pfhrp2/3-deleted P. falciparum …
Genetic surveillance of Plasmodium falciparum reveals rapid population changes following first-line treatment policy revisions in the Greater Mekong Subregion
TD Verschuuren, V Wasakul, N Thuy-Nhien, E Booth… - medRxiv, 2024 - medrxiv.org
Background: Genetic surveillance of Plasmodium falciparum (Pf) is an important tool for
tracking antimalarial resistant strains, informing decision-making by National Malaria Control …
tracking antimalarial resistant strains, informing decision-making by National Malaria Control …
Genome-wide association study of global Plasmodium vivax populations provides insights into the evolution of drug resistance
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions
has led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine …
has led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine …
[图书][B] Examining the role of PfCRT in piperaquine-resistant P. falciparum malaria to predict the emergence of piperaquine resistance in Africa
LM Hagenah - 2024 - search.proquest.com
The emergence and spread of drug resistance in Plasmodium falciparum has consistently
been a major barrier to the control and eradication of malaria. Resistance to the affordable …
been a major barrier to the control and eradication of malaria. Resistance to the affordable …