Mathematical modelling is increasingly becoming an indispensable tool for the study of
cellular processes, allowing their analysis in a systematic and comprehensive manner. In …

The mechanistic target of rapamycin (mTOR) is a central regulatory pathway that integrates
a variety of environmental cues to control cellular growth and homeostasis by intricate …

Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the
industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to …

Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides.
Formate also interacts with energy metabolism by promoting the synthesis of adenine …

Reprogramming of energy metabolism is a hallmark of cancer that enables the cancer cells
to meet the increased energetic requirements due to uncontrolled proliferation. One …

Long-term exposure to bisphenol A (BPA) in humans may promote ovarian cancer
development. In present study, the mechanisms by which BPA mediates the aggression …

The bond graph approach to modelling biochemical networks is extended to allow
hierarchical construction of complex models from simpler components. This is made …

As malignant transformation requires synchronization of growth-driving signaling (S) and
metabolic (M) pathways, defining cancer-specific SM interconnected networks (SMINs) …

The advent of high-throughput genomics techniques, along with the completion of genome
sequencing projects, identification of protein–protein interactions and reconstruction of …

Signal integration has a crucial role in the cell fate decision and dysregulation of the cellular
signaling pathways is a primary characteristic of cancer. As a signal integrator, mTOR shows …