The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Activation of microglia by classical inflammatory mediators can convert astrocytes into a
neurotoxic A1 phenotype in a variety of neurological diseases,. Development of agents that …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …

INTRODUCTION Parkinson's disease (PD) is the second most common neurodegenerative
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …

The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a
form of cell death mediated by poly (ADP-ribose) polymerase 1 (PARP1), which is caused by …

Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to
DNA lesions and catalyzes poly (ADP-ribosyl) ation of nuclear acceptor proteins, including …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …