[HTML][HTML] Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
[HTML][HTML] Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
Intracellular chloride regulation mediates local sleep pressure in the cortex
Extended wakefulness is associated with reduced performance and the build-up of sleep
pressure. In the cortex, this manifests as changes in network activity. These changes show …
pressure. In the cortex, this manifests as changes in network activity. These changes show …
Molecular architecture of the mammalian circadian clock
CL Partch, CB Green, JS Takahashi - Trends in cell biology, 2014 - cell.com
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …
temporal homeostasis with the external environment. The molecular clocks that drive these …
[HTML][HTML] Circadian clock interaction with HIF1α mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle
Circadian clocks are encoded by a transcription-translation feedback loop that aligns
energetic processes with the solar cycle. We show that genetic disruption of the clock …
energetic processes with the solar cycle. We show that genetic disruption of the clock …
Molecular mechanism of the repressive phase of the mammalian circadian clock
The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
Circadian clock-mediated regulation of blood pressure
LG Douma, ML Gumz - Free radical biology and medicine, 2018 - Elsevier
Most bodily functions vary over the course of a 24 h day. Circadian rhythms in body
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …
Molecular components of the Mammalian circadian clock
ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …
the environment. This is achieved by ocular photoreception relaying signals to the …
[HTML][HTML] Diet diurnally regulates small intestinal microbiome-epithelial-immune homeostasis and enteritis
Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food-and
microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which …
microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which …
REV-ERB and ROR nuclear receptors as drug targets
DJ Kojetin, TP Burris - Nature reviews Drug discovery, 2014 - nature.com
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …