Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A
major approach to studying PrP functions is the use of PrP gene-knockout (Prnp−/−) mice …

Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrPC) influences PrPC
misfolding into the disease-associated isoform, PrPres, as well as prion propagation and …

The development of multiple cell culture models of prion infection over the last two decades
has led to a significant increase in our understanding of how prions infect cells. In particular …

The mechanism by which pathogenic mutations in the globular domain of the cellular prion
protein (PrP C) increase the likelihood of misfolding and predispose to diseases is not yet …

The development of antibodies with binding capacity towards soluble oligomeric forms of
PrPSc recognised in the aggregation process in early stage of the disease would be of …

Although there is currently no effective treatment for prion diseases, significant advances
have been made in suppressing its progress, using antibodies that block the conversion of …

In this work we described preparation of the novel cell lines expressing human prion protein
on PrP0/0-background. Prepared cell lines originated from the Nagasaki mice (PrP0/0) and …

The pathogenesis of a disease involves a stochastic refolding of the etiologic protein into a
misfolded infectious state known as prion. Recently, there has been renewed interest in the …

4. 作出したヒツジ PrPC 発現細胞株に従来型スクレイピープリオン感染ヒツジ脳乳剤 (# 79 および#
52) または CH1641 型スクレイピープリオン感染ヒツジ脳乳剤 (# 56) を暴露し, 細胞での PrPSc …