Glioblastoma extensively infiltrates the brain; despite surgery and aggressive therapies, the
prognosis is poor. A multidisciplinary approach combining mathematical, clinical and …

The prognosis of patients with glioblastoma (GBM) remains poor, and the use of
hyperfractionation or dose escalation beyond 60 Gy has not conferred any survival benefit …

Glioblastoma multiforme (GBM) is a highly invasive primary brain tumour that has poor
prognosis despite aggressive treatment. A hallmark of these tumours is diffuse invasion into …

Radiation (RT) remains the most frequently used treatment against cancer. The main
limitation of RT is its lack of specificity for cancer tissues and the limited maximum radiation …

Tumor heterogeneity is widely considered to be a determinant factor in tumor progression
and in particular in its recurrence after therapy. Unfortunately, current medical techniques …

Gliomas differ from many other tumors as they grow infiltratively into the brain parenchyma
rather than forming a solid tumor mass with a well-defined boundary. Tumor cells can be …

Purpose To simulate and analyze the dosimetric differences of intraoperative radiotherapy
(IORT) or pre-operative single-fraction stereotactic radiosurgery (SRS) in addition to post …

This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …

In this paper an advanced, clinically oriented multiscale cancer model of breast tumor
response to chemotherapy is presented. The paradigm of early breast cancer treated by …

Glioblastoma remains a clinical challenge in spite of years of extensive research. Novel
approaches are needed in order to integrate the existing knowledge. This is the potential …