Therapeutic strategies for hepatitis B virus infection: towards a cure

GC Fanning, F Zoulim, J Hou, A Bertoletti - Nature reviews Drug …, 2019 - nature.com
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …

Vaccination of haemopoietic stem cell transplant recipients: guidelines of the 2017 European Conference on Infections in Leukaemia (ECIL 7)

C Cordonnier, S Einarsdottir, S Cesaro… - The Lancet infectious …, 2019 - thelancet.com
Infection is a main concern after haemopoietic stem cell transplantation (HSCT) and a major
cause of transplant-related mortality. Some of these infections are preventable by …

Adaptive immunity in HBV infection

A Bertoletti, C Ferrari - Journal of hepatology, 2016 - Elsevier
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …

Liver-mediated adaptive immune tolerance

M Zheng, Z Tian - Frontiers in immunology, 2019 - frontiersin.org
The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …

Targeting innate and adaptive immune responses to cure chronic HBV infection

AJ Gehring, U Protzer - Gastroenterology, 2019 - Elsevier
Fewer than 1% of chronic hepatitis B virus infections per year are cured with antiviral
treatment. This creates a need for long-term treatment, which poses challenges for patients …

Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors

W Yeo, PKS Chan, S Zhong, WM Ho… - Journal of medical …, 2000 - Wiley Online Library
Hepatitus B virus (HBV) reactivation is a well‐described complication in cancer patients who
receive cytotoxic chemotherapy and may result in varying degrees of liver damage. As …

[PDF][PDF] Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy

W Yeo, PJ Johnson - Hepatology, 2006 - Wiley Online Library
It is estimated conservatively that more than one third of the world's population has been
infected with the hepatitis B virus (HBV) and that there are 350 million people with chronic …

Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies

G Lalazar, D Rund, D Shouval - British journal of haematology, 2007 - Wiley Online Library
The prevalence of hepatitis B virus (HBV) infection in patients with haematological
malignancies is increased compared with the general population worldwide. HBV …

Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation

T Guillaume, DB Rubinstein… - Blood, The Journal of the …, 1998 - ashpublications.org
APPROXIMATELY 10,000 autologous hematopoietic stem cell (HSC) transplants are
performed worldwide each year for malignant diseases. 1 Results of randomized trials in …

[HTML][HTML] Immunotherapy for chronic hepatitis B virus infection

A Bertoletti, N Le Bert - Gut and liver, 2018 - ncbi.nlm.nih.gov
While new therapies for chronic hepatitis C virus infection have delivered remarkable cure
rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal …