The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY,
which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by
generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Mendelian …