Bottom-up synthetic immunology

K Göpfrich, M Platten, F Frischknecht… - Nature …, 2024 - nature.com
Infectious diseases and cancer evade immune surveillance using similar mechanisms.
Targeting immune mechanisms using common strategies thus represents a promising …

Manganese Dioxide-Entrapping Dendrimers Co-Deliver Protein and Nucleotide for Magnetic Resonance Imaging-Guided Chemodynamic/Starvation/Immune Therapy …

Y Gao, Z Ouyang, S Shen, H Yu, B Jia, H Wang… - ACS …, 2023 - ACS Publications
Development of a nanoscale drug delivery system that can simultaneously exert efficient
tumor therapeutic efficacy while creating the desired antitumor immune responses is still …

DNA-origami-based precise molecule assembly and their biological applications

G Li, C Chen, Y Li, B Wang, J Wen, M Guo, M Chen… - Nano Letters, 2024 - ACS Publications
Inspired by efficient natural biomolecule assembly with precise control on key parameters
such as distance, number, orientation, and pattern, the constructions and applications of …

DNA Nanostructures: Advancing Cancer Immunotherapy

Q Chen, Y Liu, Q Chen, M Li, L Xu, B Lin, Y Tan, Z Liu - Small, 2024 - Wiley Online Library
Cancer immunotherapy is a groundbreaking medical revolution and a paradigm shift from
traditional cancer treatments, harnessing the power of the immune system to target and …

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

K Pekayvaz, C Losert, V Knottenberg, C Gold… - Nature Medicine, 2024 - nature.com
Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality.
Inflammation is considered a key pathogenic driver of these diseases, but the underlying …

DNA Origami Enhanced Cytokine Immunotherapy for Alleviating Renal Ischemia-Reperfusion Injury

Y Fan, C Wang, W Dai, Y Zhou, G Lu… - … Applied Materials & …, 2024 - ACS Publications
Renal ischemia-reperfusion injury (IRI) is a major contributing factor to the development of
acute kidney injury (AKI) and has resulted in considerable morbidity and mortality. Persistent …

Decoupling individual host response and immune cell engager cytotoxic potency

C Gonzàlez Gutierrez, A Aimard, M Biarnes-Pélicot… - ACS Nano, 2025 - ACS Publications
Immune cell engagers are molecular agents, usually antibody-based constructs, engineered
to recruit immune cells against cancer cells and kill them. They are versatile and powerful …

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning

J Luo, M Molbay, Y Chen, I Horvath, K Kadletz… - Nature …, 2025 - nature.com
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a
lack of methods to analyze its cell-level biodistribution across whole organisms. Here we …

Spacer-Programmed Two-Dimensional DNA Origami Assembly

Y Liu, Z Dai, X Xie, B Li, S Jia, Q Li, M Li… - Journal of the …, 2024 - ACS Publications
Two-dimensional (2D) DNA origami assembly represents a powerful approach to the
programmable design and construction of advanced 2D materials. Within the context of …

Models and simulations of structural DNA nanotechnology reveal fundamental principles of self-assembly

A Cumberworth, A Reinhardt - Chemical Society Reviews, 2025 - pubs.rsc.org
DNA is not only a centrally important molecule in biology: the specificity of bonding that
allows it to be the primary information storage medium for life has also allowed it to become …