New methods for preparation of tailor-made fluorine-containing compounds are in extremely
high demand in nearly every sector of chemical industry. The asymmetric construction of …

Alkyl fluorides modulate the conformation, lipophilicity, metabolic stability, and pKa of
compounds containing aliphatic motifs and, therefore, have been valuable for medicinal …

Optically active α-arylation carbonyl units are widely present in a wide variety of drugs,
bioactive natural products, and valuable pharmacologically active molecules. Catalytic …

An asymmetric palladium and copper co‐catalyzed Heck/Sonogashira reaction between o‐
iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed. In …

The construction of chiral tetrasubstituted carbon stereocenters is an ongoing challenge in
synthetic organic chemistry due to its prevalence in multiple disciplines. One efficient …

Contrary to the traditional implementation as a difluoromethyl group and recently disclosed
role of C1 synthons in synthetic organic chemistry, difluorocarbene (: CF2) is reported herein …

This article provides an overview of the development of palladium-catalyzed coupling
reactions and the effects of ligand properties on the chemoselectivity of aryl (pseudo) …

An operationally simple photochemical strategy for the direct arylation of oxindoles with
(hetero) aryl halides in the absence of both transition metals and photoredox catalysts has …

Despite much progress has been made in the asymmetric α‐arylation reactions of cyclic
ketones, lactones and lactams, the enantioselective α‐arylation of acyclic carbonyl …

Chiral gem (1, 1)-diaryl containing tertiary or quaternary stereogenic centers are present in
many natural products and important pharmacophores. While numerous catalytic …