B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

B cell abnormalities contribute to the development and progress of autoimmune disease.
Traditionally, the role of B cells in autoimmune disease was thought to be predominantly …

Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC
chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked …

Summary microRNA-155 (miR-155) is expressed by cells of the immune system after
activation and has been shown to be required for antibody production after vaccination with …

The ability of B cells to negatively regulate cellular immune responses and inflammation has
only recently been described. Hallmark papers from a number of distinguished laboratories …

Background Tumor-infiltrating T cells are associated with survival in epithelial ovarian
cancer (EOC), but their functional status is poorly understood, especially relative to the …

T cell help for antibody production is a fundamental aspect of immune responses. Only
recently has a better understanding of the cellular and molecular mechanisms for T cell help …

Objective Safer and more effective therapies are needed for the treatment of systemic lupus
erythematosus (SLE). B lymphocytes have been shown to play fundamental pathogenic …

B lymphocytes can both positively and negatively regulate cellular immune responses.
Previous studies have demonstrated augmented T cell-mediated tumor immunity in …

B cells positively regulate immune responses through antibody production and optimal
CD4+ T‐cell activation. However, a specific and functionally important subset of B cells can …