Therapeutic nanoparticles and their targeted delivery applications

AA Yetisgin, S Cetinel, M Zuvin, A Kosar, O Kutlu - Molecules, 2020 - mdpi.com
Nanotechnology offers many advantages in various fields of science. In this regard,
nanoparticles are the essential building blocks of nanotechnology. Recent advances in …

Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

M Jeong, Y Lee, J Park, H Jung, H Lee - Advanced drug delivery reviews, 2023 - Elsevier
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

[HTML][HTML] Applications of nanoparticle systems in drug delivery technology

SAA Rizvi, AM Saleh - Saudi pharmaceutical journal, 2018 - Elsevier
The development of nanoparticle-based drug formulations has yielded the opportunities to
address and treat challenging diseases. Nanoparticles vary in size but are generally ranging …

Engineered nanomedicines with enhanced tumor penetration

J Ding, J Chen, L Gao, Z Jiang, Y Zhang, M Li, Q Xiao… - Nano Today, 2019 - Elsevier
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy

SY Li, H Cheng, BR Xie, WX Qiu, JY Zeng, CX Li… - ACS …, 2017 - ACS Publications
Selectively cuting off the nutrient supply and the metabolism pathways of cancer cells would
be a promising approach to improve the efficiency of cancer treatment. Here, a cancer …

Rational design of cancer nanomedicine: nanoproperty integration and synchronization

Q Sun, Z Zhou, N Qiu, Y Shen - Advanced materials, 2017 - Wiley Online Library
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers

Z Zhao, A Ukidve, V Krishnan, S Mitragotri - Advanced drug delivery …, 2019 - Elsevier
Over the years, a plethora of materials–natural and synthetic–have been engineered at a
nanoscopic level and explored for drug delivery. Nanocarriers based on such materials …

mRNA vaccine delivery using lipid nanoparticles

AM Reichmuth, MA Oberli, A Jaklenec… - Therapeutic …, 2016 - Taylor & Francis
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …

The intracellular and extracellular microenvironment of tumor site: the trigger of stimuli‐responsive drug delivery systems

X Jing, H Hu, Y Sun, B Yu, H Cong, Y Shen - Small Methods, 2022 - Wiley Online Library
The tumor microenvironment (TME), including intracellular and extracellular
microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen …