Is antioxidant therapy a useful complementary measure for Covid-19 treatment? An algorithm for its application

ME Soto, V Guarner-Lans, E Soria-Castro… - Medicina, 2020 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the corona virus
disease-19 which is accompanied by severe pneumonia, pulmonary alveolar collapses and …

Sepsis and oxidative stress in the newborn: from pathogenesis to novel therapeutic targets

C Poggi, C Dani - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Sepsis is at present one of the leading causes of morbidity and mortality in the neonatal
population. Together with inflammation, oxidative stress is involved in detrimental pathways …

[HTML][HTML] Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress

M Alorabi, S Cavalu, HM Al-Kuraishy… - Biomedicine & …, 2022 - Elsevier
Nephrotoxicity (NT) is a renal-specific situation caused by different toxins and drugs like non-
steroidal anti-inflammatory drugs (NSAIDs). NSAIDs like diclofenac (DCF) lead to glomerular …

[HTML][HTML] Antioxidants and pentoxifylline as coadjuvant measures to standard therapy to improve prognosis of patients with pneumonia by COVID-19

AP Chavarría, RRV Vázquez, JGD Cherit… - Computational and …, 2021 - Elsevier
The type 2 coronavirus causes severe acute respiratory syndrome (SARS-CoV-2) and
produces pneumonia with pulmonary alveolar collapse. In some cases it also causes sepsis …

Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2

AO Elzupir - Journal of Biomolecular Structure and Dynamics, 2022 - Taylor & Francis
In December 2019, a new coronavirus named severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) led to the outbreak of a pulmonary disease called COVID-19 …

Immunomodulation to prevent or treat neonatal sepsis: past, present, and future

SS Schüller, BW Kramer, E Villamor, A Spittler… - Frontiers in …, 2018 - frontiersin.org
Despite continued advances in neonatal medicine, sepsis remains a leading cause of death
worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates …

Pentoxifylline and thiamine ameliorate rhabdomyolysis-induced acute kidney injury in rats via suppressing TLR4/NF-κB and NLRP-3/caspase-1/gasdermin mediated …

L Al-Kharashi, H Attia, A Alsaffi, T Almasri… - Toxicology and Applied …, 2023 - Elsevier
Acute kidney injury (AKI) is a common complication of rhabdomyolysis (RM), a syndrome
characterized by skeletal muscle damage resulting in renal tubular oxidative stress …

Phosphodiesterase inhibitors in acute lung injury: what are the perspectives?

D Mokra, J Mokry - International Journal of Molecular Sciences, 2021 - mdpi.com
Despite progress in understanding the pathophysiology of acute lung damage, currently
approved treatment possibilities are limited to lung-protective ventilation, prone positioning …

Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis

X Yang, Z Xu, S Hu, J Shen - Frontiers in Pharmacology, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3 …

Design and rationale of a multicenter defeat alcoholic steatohepatitis trial:(DASH) randomized clinical trial to treat alcohol-associated hepatitis

S Dasarathy, MC Mitchell, B Barton, CJ McClain… - Contemporary clinical …, 2020 - Elsevier
Background/aims Despite high mortality of alcohol-associated hepatitis, there has been
limited advancement in treatment strategies. Defeat Alcoholic Steatohepatitis (DASH) is a …