Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on
neighboring cells. The ensuing bidirectional signals have emerged as a major form of …

Mammalian motor behavior is enabled by a hierarchy of interleaved circuit modules
constructed by interneurons in the spinal cord, sensory feedback loops, and bilateral …

Astrocytes are critical participants in synapse development and function, but their role in
synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to …

Eph receptors and their membrane-tethered ligands have important functions in
development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote …

The development of precise connectivity patterns during the establishment of the nervous
system depends on the regulated action of diverse, conserved families of guidance cues …

Determining how axon guidance receptors transmit signals to allow precise pathfinding
decisions is fundamental to our understanding of nervous system development and may …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …