Small bioactive peptides for biomaterials design and therapeutics

IW Hamley - Chemical reviews, 2017 - ACS Publications
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …

Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

J Xu, AR Khan, M Fu, R Wang, J Ji, G Zhai - Journal of Controlled Release, 2019 - Elsevier
The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport

C Díaz-Perlas, B Oller-Salvia, M Sánchez-Navarro… - Chemical …, 2018 - pubs.rsc.org
The blood–brain barrier (BBB) hampers the delivery of therapeutic proteins into the brain.
BBB-shuttle peptides have been conjugated to therapeutic payloads to increase the …

Conjugation of therapeutic psd-95 inhibitors to the cell-penetrating peptide tat affects blood–brain barrier adherence, uptake, and permeation

M Kristensen, K Kucharz, E Felipe Alves Fernandes… - Pharmaceutics, 2020 - mdpi.com
Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic
density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D …

Anti-microRNA targeting using peptide-based nanocomplexes to inhibit differentiation of human pancreatic stellate cells

J Schnittert, PR Kuninty, TF Bystry, R Brock… - …, 2017 - Taylor & Francis
Aim: To develop novel peptide-based nanocomplexes (NCs) for delivery of anti-miRNA
oligonucleotides to human-derived pancreatic stellate cells (hPSCs), precursors of cancer …

The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering

S Streck, AJ Clulow, HM Nielsen, T Rades… - Journal of colloid and …, 2019 - Elsevier
Hypothesis The distribution of three cell-penetrating peptides (CPPs) with different
architectures (short, long linear and branched) on poly (lactic-co-glycolic) acid (PLGA) …

Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive …

E Bartolami, C Bouillon, P Dumy, S Ulrich - Chemical Communications, 2016 - pubs.rsc.org
Bioactive low-molecular-weight compounds are actively pursued, as an alternative to
macromolecules, for biomedical applications such as drug and gene delivery. However …

Interactions of cell-penetrating peptide-modified nanoparticles with cells evaluated using single particle tracking

S Streck, SSR Bohr, D Birch, T Rades… - ACS applied bio …, 2021 - ACS Publications
Cell-penetrating peptides (CPPs) are known to interact with cell membranes and by doing
so enhance cellular interaction and subsequent cellular internalization of nanoparticles. Yet …

Enhanced intracellular peptide delivery by multivalent cell-penetrating peptide with bioreducible linkage

H Kim, M Kitamatsu, T Ohtsuki - Bioorganic & medicinal chemistry letters, 2018 - Elsevier
Multivalent cell-penetrating peptides (CPPs) have been reported to show enhancement in
cellular uptake and endosomolytic activity. However, its application was limited to trans …