DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …

Breast cancer is most common in women and most difficult to manage that causes highest
mortality and morbidity among all diseases and posing significant threat to mankind as well …

Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …

A general and highly efficient method for the electrochemical C (sp2)–H amination of
aldehyde hydrazones with azoles has been developed. This reaction proceeds under …

Abstract Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the
development of anticancer agents. In this study, a series of carbazole derivatives containing …

Metal based salen complexes have been considered as an important scaffold toward
targeting of DNA structures. In the present work, we have synthesized nickel (II) and …

Inspired by the common structural characteristics of numerous known antitumor compounds
targeting DNA or topoisomerase I, 3-(benzazol-2-yl)-quinoxaline-based scaffold was …

Abstract Five complexes,[Cu (L) 2]· 4.5 H 2 O (1),[Cu (HL) 2](NO 3) 2· CH 3 OH (2){[Cu 2 (L)
2 (NO 3)(H 2 O) 2]·(NO 3)} n (3),[Cu 2 (HL) 2 (SO 4) 2]· 2CH 3 OH (4) and [Cu 4 (L) 4 Cl 4] …

A series of pyrazoline derivatives (5) were synthesized in 92–96% yields from chalcones (3)
and hydrazides (4). Subsequently, topo-I and IIα-mediated relaxation and antiproliferative …

Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the
development of anticancer agents. In this study, a series of 1, 3-benzoazolyl-substituted …