An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases

DM Teleanu, AG Niculescu, II Lungu, CI Radu… - International journal of …, 2022 - mdpi.com
Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …

[HTML][HTML] The role of selenium in pathologies: an updated review

G Barchielli, A Capperucci, D Tanini - Antioxidants, 2022 - mdpi.com
Selenium is an essential microelement required for a number of biological functions.
Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 …

[HTML][HTML] Ferroptosis in Parkinson's disease: glia–neuron crosstalk

ZL Wang, L Yuan, W Li, JY Li - Trends in molecular medicine, 2022 - cell.com
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

BG Trist, DJ Hare, KL Double - Aging cell, 2019 - Wiley Online Library
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Linking neuroinflammation and neurodegeneration in Parkinson's disease

G Gelders, V Baekelandt… - Journal of immunology …, 2018 - Wiley Online Library
Neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease
(AD) impose a pressing burden on our developed and consequently aging society …

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

V Calabrese, A Santoro, D Monti, R Crupi… - Free Radical Biology …, 2018 - Elsevier
In order to better understand the pathogenesis of Parkinson's Disease (PD) it is important to
consider possible contributory factors inherent to the aging process, as age-related changes …

Rotenone-induced model of Parkinson's disease: Beyond mitochondrial complex I inhibition

MT Ibarra-Gutiérrez, N Serrano-García… - Molecular …, 2023 - Springer
Parkinson's disease (PD) is usually diagnosed through motor symptoms that make the
patient incapable of carrying out daily activities; however, numerous non-motor symptoms …

NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols

SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Oxidative stress and lipotoxicity

AK Hauck, DA Bernlohr - Journal of lipid research, 2016 - ASBMB
The α, β polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify
lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play …

Oxidative stress in Parkinson's disease: Potential benefits of antioxidant supplementation

S Percário, A da Silva Barbosa… - Oxidative medicine …, 2020 - Wiley Online Library
Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …