[HTML][HTML] Natural health products (NHP's) and natural compounds as therapeutic agents for the treatment of cancer; mechanisms of anti-cancer activity of natural …

B Scaria, S Sood, C Raad, J Khanafer… - International Journal of …, 2020 - mdpi.com
Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic,
non-selective effects. These harmful side-effects drastically reduce the cancer patient's …

Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study

EJC de Blanco, EM Addo, HL Rakotondraibe… - Natural Product …, 2023 - pubs.rsc.org
Covering up to early 2023 The present review summarizes recent accomplishments made
as part of a multidisciplinary, multi-institutional anticancer drug discovery project, wherein …

[HTML][HTML] Formulation of gold nanoparticles with hibiscus and curcumin extracts induced anti-cancer activity

S Akhtar, SM Asiri, FA Khan, ST Gunday, A Iqbal… - Arabian Journal of …, 2022 - Elsevier
Gold nanoparticles (AuNPs) have shown a potential for biological applications due to their
biocompatibility and high efficiency in drug delivery. Most of the times, the chemical routs are …

Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE …

HO Rasul, BK Aziz, DD Ghafour, A Kivrak - Molecular Diversity, 2023 - Springer
One of the most common malignancies diagnosed and the leading cause of death for cancer-
stricken women globally is breast cancer. The molecular subtype affects therapy options …

[HTML][HTML] Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics

C Nguyen, K Baskaran, A Pupulin, I Ruvinov… - … and alternative medicine, 2019 - Springer
Background Current therapeutic approaches to treat metastatic breast cancer, although
effective, have shown many inadvertent side effects such as genotoxicity due to a lack of …

Biosynthetic gold nanoparticles of Hibiscus syriacus L. callus potentiates anti-inflammation efficacy via an autophagy-dependent mechanism

XY Xu, THM Tran, H Perumalsamy… - Materials Science and …, 2021 - Elsevier
Biological applications of gold nanoparticles (AuNps) have potentially explored an efficient
agent attributed to their biocompatibility and high efficiency in drug delivery. Our study …

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo

A Zeng, H Hua, L Liu, J Zhao - Bioorganic & medicinal chemistry, 2019 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpenoids extracted from birch with a wide range of
biological properties. Recent studies have shown that BA has significant cytotoxicity to …

[HTML][HTML] Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models

AQ Zeng, Y Yu, YQ Yao, FF Yang, M Liao, LJ Song… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Breast cancer is the most common female cancer with considerable metastatic potential,
explaining the need for new candidates that inhibit tumor metastasis. In our study, betulinic …

[HTML][HTML] Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review

MH Cháirez-Ramírez, MR Moreno-Jiménez… - EXCLI …, 2016 - ncbi.nlm.nih.gov
In recent times, a great deal of interest has been motivated on plant derived compounds
known as nutraceuticals. These compounds exert important beneficial activities that improve …

[HTML][HTML] Natural compounds in sex hormone-dependent cancers: The role of triterpenes as therapeutic agents

C Şoica, M Voicu, R Ghiulai, C Dehelean… - Frontiers in …, 2021 - frontiersin.org
Sex hormone-dependent cancers currently contribute to the high number of cancer-related
deaths worldwide. The study and elucidation of the molecular mechanisms underlying the …