The genus Enterococcus includes some of the most important nosocomial multidrug-
resistant organisms, and these pathogens usually affect patients who are debilitated by …

Highlights•Enterococcus faecium is gaining prominence as a nosocomial
pathogen.•Genome expansion is a distinguishing feature of health-care associated E …

Background Daptomycin is a lipopeptide with bactericidal activity that acts on the cell
membrane of enterococci and is often used off-label to treat patients infected with …

Treatment of multidrug-resistant enterococci has become a challenging clinical problem in
hospitals around the world due to the lack of reliable therapeutic options. Daptomycin (DAP) …

Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human
gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a …

Background Enterococci are among the leading causes of hospital-acquired infections in the
United States and Europe, with Enterococcus faecalis and Enterococcus faecium being the …

Extrachromosomal elements are ubiquitous in the prokaryotic world and play important roles
in the adaptation and survival of cell populations, especially in changing environments …

Bacteria have developed several evolutionary strategies to protect their cell membranes
(CMs) from the attack of antibiotics and antimicrobial peptides (AMPs) produced by the …

Development of daptomycin (DAP) resistance in Enterococcus faecalis has recently been
associated with mutations in genes encoding proteins with two main functions:(i) control of …

Firmicutes constitutes one of the dominant bacteria phyla of human and animal gut
microbiota. It comprises a number of genera of outstanding relevance in health care and …