Dodging matrix effects in liquid chromatography tandem mass spectrometric assays—compilation of key learnings and perspectives

NR Srinivas - Biomedical Chromatography, 2009 - Wiley Online Library
Triple quad liquid chromatography mass spectrometric assays (LC/MS/MS) have
revolutionized the analysis of drug (s)/metabolite (s) with exceptional speed, sensitivity and …

The influence of citrate, EDTA, and heparin anticoagulants to human plasma LC–MS lipidomic profiling

V Gonzalez-Covarrubias, A Dane, T Hankemeier… - Metabolomics, 2013 - Springer
Lipid profiling of human plasma by liquid chromatography-electrospray ionization coupled to
mass spectrometry (LC–ESI-MS) is being used to identify biomarkers of health, disease, and …

Niacin and its metabolites: role of LC‐MS/MS bioanalytical methods and update on clinical pharmacology. An overview

R Mullangi, NR Srinivas - Biomedical Chromatography, 2011 - Wiley Online Library
Niacin (nicotinic acid), although an old drug, has seen a sudden surge in popularity for
treatment of lipid disorders and other associated clinical conditions for the prevention of …

Reactive charged droplets for reduction of matrix effects in electrospray ionization mass spectrometry

DS Kulyk, CF Miller, AK Badu-Tawiah - Analytical chemistry, 2015 - ACS Publications
A new quantitative contained-electrospray (ES) process is described here that employs a
movable ES emitter to control the reactivity of charged microdroplets by varying their …

UPLC–MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues

J Huang, N Gautam, SPR Bathena, U Roy… - … of Chromatography B, 2011 - Elsevier
Animal pharmacokinetic and tissue distribution assays of antiretroviral therapeutic drugs
require accurate drug quantification in biological fluids and tissues. Here we report a simple …

Simultaneous quantification of niacin and its three main metabolites in human plasma by LC–MS/MS

M Liu, D Zhang, X Wang, L Zhang, J Han… - … of Chromatography B, 2012 - Elsevier
A sensitive and specific LC–MS/MS method for the simultaneous quantification of niacin
(NA) and its three main metabolites nicotinamide (NAM), nicotinuric acid (NUA) and N …

Simultaneous determination of niacin and its metabolites—nicotinamide, nicotinuric acid and N‐methyl‐2‐pyridone‐5‐carboxamide—in human plasma by LC‐MS …

JK Inamadugu, R Damaramadugu… - Biomedical …, 2010 - Wiley Online Library
Abstract An LC‐MS/MS method for the simultaneous quantitation of niacin (NA) and its
metabolites, ie nicotinamide (NAM), nicotinuric acid (NUA) and N‐methyl‐2‐pyridone‐5 …

Simultaneous determination of atorvastatin and niacin in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study

VB Ravi, R Mullangi, JK Inamadugu… - Biomedical …, 2012 - Wiley Online Library
ABSTRACT A rapid, simple, sensitive and selective LC‐MS/MS method has been developed
and validated for quantification of the atorvastatin (AT) and niacin (NA) in 250 μL human …

Mechanistic evaluation of matrix effect on three different model of mass spectrometer by using a model drug

P Vats, SM Verma, T Monif - … of Analytical & …, 2016 - bournemouth-computer-sales.com
In this research work we have tried to emphasis that the synergistic approach is required
wherein during method development sample processing and instrument ie, mass …

Dilemma with Matrix Effect in Bioanalysis–Perspectives from Bioavailability/Bioequivalence Studies for Product Registration?

NR Srinivas - Drug research, 2014 - thieme-connect.com
Sir: In this age of triple quad mass spectrometric use (LC-MS/MS) for highly sensitive
bioanalytical assays, the heightened awareness of challenges with matrix effects has led to …