Previous research into hyaluronan (HA) has focused on the role of this abundant tissue
glycosaminoglycan in promoting cell migration through interactions with its transmembrane …

CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major
hyaluronan receptor on most cell types. Although alternative splicing can produce a large …

CD44 is the primary cell surface receptor for the extracellular matrix glycosaminoglycan
hyaluronan. Here we determined the relative avidities of unlabeled hyaluronan preparations …

The glycosaminoglycan hyaluronan is a key substrate for cell migration in tissues during
inflammation, wound healing, and neoplasia. Unlike other matrix components, hyaluronan …

Regulation of transient interactions between cells and the ubiquitous matrix
glycosaminoglycan hyaluronan is crucial to such fundamental processes as embryonic …

Hyaluronan oligosaccharides (molecular weight:∼ 2.5× 10 3) inhibit growth of several types
of tumors in vivo. In vitro, the oligomers inhibit anchorage-independent growth of several …

A role for the membrane/cytoskeleton interface in the development and progression of
cancer is established, yet poorly understood. The neurofibromatosis type II (NF2) tumor …

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie
fundamental processes such as inflammatory leukocyte homing and tumor metastasis …

Introduction 3. The extracellular domain 3.1. The conserved region 3.1. 1. The link module
3.1. 2. N-glycosylation sites 3.1. 3. Outside the link module 3.2 The non-conserved region …

A major obstacle to successful treatment of colorectal cancer is chemotherapy resistance.
Enhanced expression of variant CD44 isoforms has been associated with aggressive tumor …