Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Abstract Sirtuin 1 (SIRT1) is the most conserved mammalian NAD+-dependent protein
deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In …

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …

Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD
salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been …

Maternal aging can impair the quality and decrease the developmental competence of
ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was …

A Autosomal-dominant ELANE mutations are the most common cause of severe congenital
neutropenia. Although the majority of congenital neutropenia patients respond to daily …

FOXO3a and FOXM1 are two forkhead transcription factors with antagonistic roles in cancer
and DNA damage response. FOXO3a functions like a typical tumour suppressor, whereas …

ABSTRACT Introduction: Nicotinamide phosphoribosyltransferase (Nampt) is the rate-
limiting enzyme that catalyzes the first step in the mammalian nicotinamide adenine …

Nampt/Visfatin/PBEF is a primary, rate-limiting enzyme involved in NAD+ biosynthesis,
which serves as a pivotal substance for proteins, and is required for cell growth, survival …