Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …

Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints.
These disorders are very painful and severely limit patients' mobility and are more common …

Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

One of the major issues in tissue engineering is regulation of stem cell differentiation toward
specific lineages. Unlike biological and chemical signals, physical signals with adjustable …

Background The mesenchymal stem cell (MSC) secretome, via the combined actions of its
plethora of biologically active factors, is capable of orchestrating the regenerative responses …

A wide range of techniques and methods are actively invented by clinicians and scientists
who are dedicated to the field of musculoskeletal tissue regeneration. Biological, chemical …

Background Developing new methods to deliver cells to the injured tissue is a critical factor
in translating cell therapeutics research into clinical use; therefore, there is a need for …

Background. Although there are many pharmacological interventions for adults with
osteoarthritis (OA) who do not meet the indications for surgery, side effects and adverse …

Mesenchymal stem cells (MSCs), as a kind of pluripotent stem cells, have attracted much
attention in orthopedic diseases, geriatric diseases, metabolic diseases, and sports …