Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …

Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Since the early days marking the first use of nanomedicine in the early 80s, there has been a
meaningful change in the scientific field involving the Fabrication, characterization, and …

Coumarin and its derivatives are widely used as scaffolds in the synthesis of new
heterocyclic systems. This review focuses on current developments in the synthesis of …

We aim to construct a hypoxia-and immune-associated risk score model to predict the
prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). By unsupervised …

Combretastatin derivatives is a promising class of antitumor agents, tubulin assembly
inhibitors. However, due to poor solubility and insufficient selectivity to tumor cells, we …

Simple Summary Despite access to a vast arsenal of anticancer agents, many fail to realise
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …

Breast cancer due to its high incidence and mortality is the second leading cause of death
among females. On the other hand, nanoparticle-based drug delivery is one of the most …

Drug delivery has made tremendous advances in the last decade. Targeted therapies are
increasingly common, with intracellular delivery highly impactful and sought after …