The covalent modification of histones is critical for many biological functions in mammals,
including gene regulation and chromatin structure. Posttranslational histone modifications …

R-loops are trimeric nucleic acid structures that form when an RNA molecule hybridizes with
its complementary DNA strand, displacing the opposite strand. These structures regulate …

In mammals, the transition from mitosis to meiosis facilitates the successful production of
gametes. However, the regulatory mechanisms that control meiotic initiation remain unclear …

Epigenetic mechanisms often fuel the quick evolution of cancer cells from normal cells.
Mutations or aberrant expressions in the enzymes of DNA methylation, histone post …

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …

Sperm production and function require the correct establishment of DNA methylation
patterns in the germline. Here, we examined the genome-wide DNA methylation changes …

SET domain-containing 2 (SETD2) is a lysine methyltransferase that catalyzes histone H3
lysine36 trimethylation (H3K36me3) and has been revealed to play important roles in the …

The pathogenesis of Hirschsprung's disease (HSCR) is complex. Recently, it has been
found that histone modifications can alter genetic susceptibility and play important roles in …

Background: Luscan-Lumish syndrome is characterized by macrocephaly, postnatal
overgrowth, intellectual disability (ID), developmental delay (DD), which is caused by …

Nucleosomes are the basic compaction unit of chromatin and nucleosome structure, and
their higher-order assemblies regulate genome accessibility. Many post-translational …