Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders.
However, the mechanism underlying this dysregulation, particularly in human cells, remains …

Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

Brain organoids are derived from induced pluripotent stem cells and embryonic stem cells
under 3-dimensional culture condition. The generation of organoid requires the self …

Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of
infarcted tissue. Although a variety of stem cell transplantation has been explored to improve …

Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …