Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Tayside is a region in the East of Scotland and forms one of nine local government regions
in the country. It is home to approximately 416,000 individuals who fall under the National …

Background and aims The efficacy of statin therapy is hindered by intolerance to the therapy,
leading to discontinuation. Variants in SLCO1B1, which encodes the hepatic transporter …

Genetic factors are recognized as risk factors for statin-associated muscle symptoms
(SAMS), which are the most common cause of statin intolerance. The aim of this study was to …

Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes spinal
inflammation and fusion. Although the cause of AS is unknown, genetic factors (eg, HLA …

Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor used in the
treatment of cancer. Atorvastatin is a statin commonly applied to treat hypercholesterolemia …

Hyperlipidemia is a significant risk factor for cardiovascular disease morbidity and mortality.
The lipid-lowering drugs are considered the cornerstone of primary and secondary …

Introduction Guidelines of management of dyslipidemias and prevention of cardiovascular
disease (CVD) are based on firm scientific evidence obtained by randomized controlled …

Simvastatin (brand name Zocor) is a member of the statin class of drugs, used to regulate
low-density lipoprotein (LDL) cholesterol levels in various conditions, including familial …

Background/Aims: Statin intolerance leads to poor adherence to statin therapy, resulting in a
failure to achieve desired cholesterol reduction and adverse outcomes. The LILRB5 …