Cyclobutanone Inhibitors of Diaminopimelate Desuccinylase (DapE) as Potential New Antibiotics
Based on our previous success in using cyclobutanone derivatives as enzyme inhibitors, we
have designed and prepared a 37-member library of α-aminocyclobutanone amides and …
have designed and prepared a 37-member library of α-aminocyclobutanone amides and …
Computer-aided Design of Wide-spectrum Coronavirus Helicase NSP13 Cage Inhibitors: A Molecular Modelling Approach
V Shiryaev, Y Klimochkin - Current Computer-Aided Drug …, 2024 - benthamdirect.com
Background: The coronavirus helicase NSP13 plays a critical role in its life cycle. The found
NSP13 inhibitors have been tested only in vitro but they definitely have the potential to …
NSP13 inhibitors have been tested only in vitro but they definitely have the potential to …
Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure
SO Asiedu, Y Gupta, V Nicolaescu, H Gula… - International journal of …, 2023 - mdpi.com
We have previously shown computationally that Mycolactone (MLN), a toxin produced by
Mycobacterium ulcerans, strongly binds to Munc18b and other proteins, presumably …
Mycobacterium ulcerans, strongly binds to Munc18b and other proteins, presumably …