Challenges in validation of combination treatment strategies for CRC using patient-derived organoids
V Benboubker, GM Ramzy, S Jacobs… - Journal of Experimental …, 2024 - Springer
Patient-derived organoids (PDOs) established from tissues from various tumor types gave
the foundation of ex vivo models to screen and/or validate the activity of many cancer drug …
the foundation of ex vivo models to screen and/or validate the activity of many cancer drug …
[HTML][HTML] Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection
FAW van Dijk, KM Bertram, TR O'Neil, Y Li, DJ Buffa… - …, 2025 - pmc.ncbi.nlm.nih.gov
Anogenital inflammation is a critical risk factor for HIV acquisition. The primary preventative
HIV intervention, pre-exposure prophylaxis (PrEP), is ineffective in blocking transmission in …
HIV intervention, pre-exposure prophylaxis (PrEP), is ineffective in blocking transmission in …
EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s
J Cuenca-Escalona, J Bödder, B Subtil… - Journal of Leukocyte …, 2024 - academic.oup.com
Tumor-derived prostaglandin E2 (PGE2) impairs antitumor immunity by priming suppressive
functions on various immune cell types, including dendritic cells (DCs). In this way, tumors …
functions on various immune cell types, including dendritic cells (DCs). In this way, tumors …
Dendritic Cells in Shaping Anti-Tumor T Cell Response
L Mazzoccoli, B Liu - Cancers, 2024 - mdpi.com
Simple Summary Cancer stands as the second leading cause of death globally. Over the
years, concerted efforts have been devoted to developing innovative and effective therapies …
years, concerted efforts have been devoted to developing innovative and effective therapies …
[PDF][PDF] Distinct roles of PGE2-EP2 and EP4 signaling in pDCs: implications for immune modulation in the tumor microenvironment
J Cuenca-Escalona, A Cambi, TD de Boer… - Tumor-derived PGE2 … - repository.ubn.ru.nl
Dendritic cells (DCs) play a pivotal role in orchestrating adaptive immunity in response to
environmental cues, including lipid mediators such as prostaglandin E2 (PGE2). In the …
environmental cues, including lipid mediators such as prostaglandin E2 (PGE2). In the …