The interaction of drugs with biological membranes is a critical factor affecting their
pharmacokinetics and pharmacodynamics, so understanding how drugs interact with …

Developing new drugs is a complex, time‐consuming, and expensive process, essential to
identify potential pharmacokinetic issues in the early stages to avoid investment in …

Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major
cause of pain and disability in older adult individuals. Oral administration of non-steroidal …

Diclofenac (DCF) is a non-steroidal anti-inflammatory drug (NSAID), commonly used for the
treatment of pain. It can inhibit prostaglandin synthesis by blocking cyclooxygenase (COX). It …

HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising
strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide …

Molecules able to prevent lipid peroxidation have attracted attention due to their potential to
act against lipid peroxidation-induced disorders including cancer and neurological …

Cardiovascular (CV) toxicity is nowadays recognized as a class effect of non-aspirin
nonsteroidal anti-inflammatory drugs (NSAIDs). However, their mechanisms of cardiotoxicity …

In this study, the potential toxicity of non-functionalized polystyrene nanoparticles (PS-NPs)
in human erythrocytes has been assessed. The effect of PS-NPs with different diameters (∼ …

Interactions of paclitaxel (PTX) with models mimicking biological interfaces (lipid
membranes and serum albumin, HSA) were investigated to test the hypothesis that the set of …

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) from the group of phenylacetic
acid derivatives, which has analgesic, anti-inflammatory and antipyretic properties. The …