The view that substance addiction is a brain disease, although widely accepted in the
neuroscience community, has become subject to acerbic criticism in recent years. These …

Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

The global tuberculosis (TB) and child health community has increasingly prioritized the
childhood TB epidemic. In 2013, the childhood TB subgroup developed and published the …

Background Inclusion health focuses on people in extremely poor health due to poverty,
marginalisation, and multimorbidity. We aimed to review morbidity and mortality data on four …

Background Harm reduction and treatment programmes are essential for reducing harms for
people who inject drugs (PWID). We aimed to update estimates from a 2017 review of global …

Opioid use disorder (OUD) is associated with a high risk of premature death. Medication-
assisted treatment (MAT) is the primary treatment for opioid dependence. We …

Executive summary In September, 2015, the member states of the UN endorsed Sustainable
Development Goals (SDGs) for 2030, which aspire to human-rights-centred approaches to …

Background The revolution in hepatitis C virus (HCV) treatment through the development of
direct-acting antivirals (DAAs) has generated international interest in the global elimination …

Abstract The United States opioid epidemic is a nationwide public health crisis. Initially
driven by increased consumption and availability of pharmaceutical opioids, an increasing …