Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …

▪ Abstract Fatty acid desaturases introduce a double bond in a specific position of long-chain
fatty acids, and are conserved across kingdoms. Degree of unsaturation of fatty acids affects …

It is generally accepted that dietary linoleate and linolenate are metabolized, respectively, to
5, 8, 11, 14^ 20: 4 and 5, 8, 11, 14, 17^ 20: 5 via the use of positionspeci¢ c v6 and v5 …

Fatty acids are critical for the normal development and function of all organisms, and in
particular, very long chain PUFAs are necessary for the health and maintenance of higher …

Because of their characteristic living environments, marine organisms produce a variety of
lipids. Fatty acids constitute the essential part of triglycerides and wax esters, which are the …

Arachidonic (20: 4 (n-6)), eicosapentaenoic (20: 5 (n-3)), and docosahexaenoic (22: 6 (n-3))
acids are major components of brain and retina phospholipids, substrates for eicosanoid …

We report the production of two very long chain polyunsaturated fatty acids, arachidonic acid
(AA) and eicosapentaenoic acid (EPA), in substantial quantities in a higher plant. This was …

It is now well established that the long-chain, omega-3 (ω3 or n-3) polyunsaturated fatty
acids (PUFA) are vitally important in human nutrition, reflecting their particular roles in critical …

When considering the evolution of desaturases, several different aspects come into focus,
the most obvious ones being phylogenetic origins and differentiation of regioselectivities of …

The insertion of double bonds into specific positions of fatty acids is achieved by the action
of distinct desaturase enzymes. Here we report the cloning and characterization of three …