Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

Cardiac glycosides have been used for decades to treat congestive heart failure. The recent
identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and …

We have shown that the caveolar Na/K-ATPase transmits ouabain signals via multiple
signalplexes. To obtain the information on the composition of such complexes, we separated …

Abstract The Na/K-ATPase was discovered by Skou in 1957. Since then, the efforts of
numerous investigators have led to the following conclusions:(a) This enzyme is indeed the …

Cardiac disease is the leading cause of death in uremic patients. In contrast to previous
opinion, coronary events account for a relatively small proportion of cardiac deaths, the most …

Digitalis-like compounds (DLC) are a family of steroid hormones synthesized in and
released from the adrenal gland. DLC, the structure of which resembles that of plant cardiac …

A major difference between the Na, K-ATPase ion pump and other P-type ATPases is its
ability to bind cardiotonic steroids such as ouabain. Na, K-ATPase also interacts with many …

A critical question in hypertension research is: How is long-term blood pressure controlled?
Excessive NaCl ingestion or NaCl retention by the kidneys and the consequent tendency …