Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series
of compounds structurally based on highly active in vivo ligands previously studied and …

Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately …

Abstract N 2, 6-Substituted 1, 3, 5-triazine-2, 4-diamines (N 2-substituted guanamines)
attracted significant interest due to their potential in the development of bioactive molecules …

Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known
in the field of molecular mechanisms. The 5-HT6R ligands can be pivotal for innovative …

A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

The complex neuroimmunological interactions mediated by chemokines are suggested to
be responsible for the development of neuropathic pain. The lack of knowledge regarding …

Parental history of opioid exposure is seldom considered when prescribing opioids for pain
relief. To explore whether parental opioid exposure may affect sensitivity to morphine in …

Undoubtedly, opioid drugs have been the most popular treatment for refractory pain since
found, such as morphine. However, tolerance to the analgesic effects caused by repeated …