Living cells are adaptive self-sustaining systems. They strictly depend on the sufficient
supply of oxygen, energy, and nutrients from the outside in order to sustain their internal …

Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of
genes; the ensemble of these binding events forms a regulatory network, constituting the …

Increasing evidence has shown that population dynamics are qualitatively different from
single-cell behaviors. Reporters to probe dynamic, single-cell behaviors are desirable yet …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating
signals from upstream sensors such as MTOR and AMPK and transducing them to the …

Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae.
Although yeast cells can utilize a wide range of carbon sources, presence of glucose …

The Atg1/ULK complex plays an essential role in the initiation of autophagy: receiving
signals of cellular nutrient status, recruiting downstream Atg proteins to the autophagosome …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …