Estrogen receptors and the aging brain

S Maioli, K Leander, P Nilsson… - Essays in Biochemistry, 2021 - portlandpress.com
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

The potential of CYP46A1 as a novel therapeutic target for neurological disorders: an updated review of mechanisms

MS Alavi, G Karimi, HA Ghanimi… - European Journal of …, 2023 - Elsevier
Cholesterol is a key component of the cell membrane that impacts the permeability, fluidity,
and functions of membrane-bound proteins. It also participates in synaptogenesis, synaptic …

The cholesterol depleting agent, (2-Hydroxypropyl)-ß-cyclodextrin, does not affect disease progression in SOD1G93A mice

L Greensmith, JB Bryson - Amyotrophic Lateral Sclerosis and …, 2023 - Taylor & Francis
Objective Previously, we demonstrated that Amyloid Precursor Protein (APP) contributes to
pathology in the SOD1G93A mouse model of ALS and that genetic ablation of APP in …