The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

Reactive oxygen species (ROS) are created in cells during oxidative phosphorylation by the
respiratory chain in the mitochondria or by the family of NADPH oxidase (NOX) complexes …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Animal models for inflammatory arthritides such as rheumatoid arthritis (RA) and psoriatic
arthritis are widely accepted and frequently used to identify pathological mechanisms and …

Background The medicinal uses of plants are in many cases based exclusively on traditional
knowledge without enough scientific evidences. Different parts of Moringa oleifera were …

Background Tripterygium glycoside tablets (TGT) is the most common preparation from
Tripterygium wilfordii Hook F, which is widely used in clinical for treating rheumatoid arthritis …

The aim of this study was to assess anti-inflammatory, anti-oxidant, anti-genotoxic and
immunomodulatory effects of honey bee venom (HBV) on adjuvant-induced arthritis in rats …

Saat ini kemajuan kedokteran mengalami kemajuan cukup pesat, penelitian eksperimental
dilaboratorium secara in vivo pada manusia seringkali terkendala masalah etik dan …

Inflammatory arthritis (IA) is a common disease that affects millions of individuals worldwide.
Proinflammatory events during IA pathogenesis are well studied; however, loss of protective …

The mechanisms underlying the transition of rheumatoid arthritis (RA) systemic
autoimmunity to the joints remain largely unknown. Here, we demonstrate that macrophages …