The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Type 2 diabetes is increasingly viewed as a disease of insulin deficiency due not only to
intrinsic pancreatic β-cell dysfunction but also to reduction of β-cell mass. It is likely that, in …

Aims The purpose of the current study was to investigate the characteristic expression of
circular RNAs (circRNAs) in the peripheral blood of type 2 diabetes mellitus (T2DM) patients …

Activation of the G-protein-coupled receptor for glucose-dependent insulinotropic
polypeptide facilitates insulin-release from pancreaticβ-cells. In the present study, we …

Glucose-dependent insulinotropic polypeptide (GIP) acts as a glucose-dependent growth
factor for β-cells. Here we show that GIP and glucose also act synergistically as anti …

The control of pancreatic β-cell growth and survival in the adult plays a pivotal role in the
pathogenesis of type 2 diabetes. In certain insulin-resistant states, such as obesity, the …

Pancreatic islet β-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis.
Consequently, knowledge of signals that regulate β-cell function is of immense clinical …

Abstract Background Circular RNA (circRNA) is involved in the pathological processes of
various diseases. CircRNA is more stable than linear RNAs and is expressed in high levels …

11beta-Hydroxysteroid dehydrogenases (11beta-HSDs) interconvert active corticosterone
and inert 11-dehydrocorticosterone. In tissue homogenates, 11beta-HSD type 1 (11beta …

The β-cell is one of four major types of cells present in the islets of Langerhans, which are
islands of cells distributed throughout the endocrine pancreas in most mammals. The β-cell …