Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
Tumor glycolysis, an essential sweet tooth of tumor cells
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
[HTML][HTML] Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers
A Comandatore, M Franczak, RT Smolenski… - Seminars in cancer …, 2022 - Elsevier
The energy metabolism of tumor cells is considered one of the hallmarks of cancer because
it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation …
it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation …
Lactate dehydrogenase: a marker of diminished antitumor immunity
S Van Wilpe, R Koornstra, M Den Brok… - …, 2020 - Taylor & Francis
Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint
inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor …
inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor …
[HTML][HTML] Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
JM Matés, FJ Di Paola, JA Campos-Sandoval… - Seminars in cell & …, 2020 - Elsevier
Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …
provide energy, biosynthetic precursors and redox requirements to allow the massive …
Potential targeting of the tumor microenvironment to improve cancer virotherapy
In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant
adeno-associated virus (AAV) delivery was also approved. However, systemic …
adeno-associated virus (AAV) delivery was also approved. However, systemic …
Reprogramming energy metabolism with synthesized PDK inhibitors based on dichloroacetate derivatives and targeted delivery systems for enhanced cancer therapy
W She, T Liu, H Li, Z Wang, Z Guo… - Journal of Medicinal …, 2023 - ACS Publications
In many types of cancers, pyruvate dehydrogenase kinase (PDK) is abnormally
overexpressed and has become a promising target for cancer therapy. However, few highly …
overexpressed and has become a promising target for cancer therapy. However, few highly …
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer
ZX Liao, IM Kempson, CC Hsieh, SJ Tseng… - Drug Discovery …, 2021 - Elsevier
Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs
because of the emergence of drug resistance and genetic mutations. The same mutations …
because of the emergence of drug resistance and genetic mutations. The same mutations …
Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung …
Lung adenocarcinoma (LUAD) is one of the most prevalent and aggressive types of lung
cancer. Metabolic reprogramming plays a critical role in the development and progression of …
cancer. Metabolic reprogramming plays a critical role in the development and progression of …
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents
Introduction One of the most distinctive hallmarks of cancer cells is increased glucose
consumption for aerobic glycolysis, which is called the Warburg effect. In recent decades …
consumption for aerobic glycolysis, which is called the Warburg effect. In recent decades …