Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …

Tripterygium hypoglaucum (Lévl.) Hutch (THH) is believed to play an important role in health
care and disease treatment according to traditional Chinese medicine. Moreover, it is also …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

Celastrol (CLT) is an active ingredient that was initially discovered and extracted from the
root of Tripterygium wilfordii. The potential pharmacological activities of CLT in cancer …

Abstract Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and cytochrome P450 (CYP)
4A-mediated arachidonic acid (AA) metabolism play an essential role in human …

Abstract Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and microsomal
prostaglandin E synthase-1 (mPGES-1)-derived eicosanoids play an essential role in …

The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook.
F. effectively ameliorates inflammation with potential as therapeutics for inflammatory …