There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

IGRAs may still be useful in high-burden settings in specific subgroups at high risk of
progression, including young children, HIV-infected individuals and healthcare workers, but …

Performance of interferon-γ (IFN-γ) release assays still needs to be improved. The data on
the performance of QuantiFERON-TB Gold Plus (QFT-Plus), a new-generation of QFT assay …

Sputum smears for acid-fast bacilli (AFB) are the primary methods for diagnosis of
tuberculosis (TB) in many countries. The tuberculin skin test (TST) is the primary method for …

A more complete understanding of cytokine dynamics in individual cells in active pulmonary
tuberculosis patients will provide further knowledge about immunopathogenesis and …

Tuberculosis (TB) caused by Mycobacterium tuberculosis constitutes an ongoing threat to
global health. An antigen that can induce dendritic cell (DC) maturation and lead to …

The tuberculin skin test for diagnosing Mycobacterium tuberculosis infection suffers from
antigenic cross-reactivity of purified protein derivative with BCG, resulting in poor specificity …

Tuberculosis remains a serious social and public health problem, affecting millions of
people annually. The bacille Calmette-Guerin (BCG) vaccine, used prophylactically, does …

Compared with the tuberculin skin test, the antigen-specific interferon-γ assay, when used in
a standardised protocol (overnight incubation assay using a combination of two antigens) for …