Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production

M Narayani, S Srivastava - Phytochemistry reviews, 2017 - Springer
Higher plants undergo a variety of stresses and to combat those stresses they acclimatize
themselves by producing diverse secondary metabolites. These secondary metabolites also …

[HTML][HTML] The role of natural products as sources of therapeutic agents for innovative drug discovery

K Dzobo - Comprehensive pharmacology, 2022 - ncbi.nlm.nih.gov
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

Integrated omics analysis of specialized metabolism in medicinal plants

A Rai, K Saito, M Yamazaki - The Plant Journal, 2017 - Wiley Online Library
Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …

[HTML][HTML] Natural bioactive products as promising therapeutics: A review of natural product-based drug development

CB Aware, DN Patil, SS Suryawanshi, PR Mali… - South African Journal of …, 2022 - Elsevier
Since ancient times, natural medicines have had paramount importance in bolstering
biotherapeutics to treat various diseases. The World Health Organization (WHO) revealed …

The current developments in medicinal plant genomics enabled the diversification of secondary metabolites' biosynthesis

MM Alami, Z Ouyang, Y Zhang, S Shu, G Yang… - International journal of …, 2022 - mdpi.com
Medicinal plants produce important substrates for their adaptation and defenses against
environmental factors and, at the same time, are used for traditional medicine and industrial …

Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

Q Wang, S Quan, H Xiao - Bioresources and Bioprocessing, 2019 - Springer
Terpenoids are a group of largest natural products with important biological functions, and
their efficient biosynthesis is of particular importance to both academia and industry. As the …

Metabolomics-driven mining of metabolite resources: Applications and prospects for improving vegetable crops

DP Singh, MS Bisen, R Shukla, R Prabha… - International Journal of …, 2022 - mdpi.com
Vegetable crops possess a prominent nutri-metabolite pool that not only contributes to the
crop performance in the fields, but also offers nutritional security for humans. In the pursuit of …

Harnessing plant biotechnology-based strategies for in vitro galanthamine (GAL) biosynthesis: A potent drug against Alzheimer's disease

H Kaur, S Chahal, P Jha, MM Lekhak… - Plant Cell, Tissue and …, 2022 - Springer
Medicinal plants are important for improving human health and represent an essential pool
for the identification of novel pharmacological leads. Plant-derived biomolecules have …

Multi-omics-based discovery of plant signaling molecules

F Luo, Z Yu, Q Zhou, A Huang - Metabolites, 2022 - mdpi.com
Plants produce numerous structurally and functionally diverse signaling metabolites, yet
only relatively small fractions of which have been discovered. Multi-omics has greatly …