Ribosome biogenesis and translation control are essential cellular processes that are
governed at numerous levels. Several tumour suppressors and proto-oncogenes have been …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an
important role in neurodegenerative diseases, however, the interplay between these two …

Metastasis is the principal event leading to death in individuals with cancer, yet its molecular
basis is poorly understood 1. To explore the molecular differences between human primary …

Overexpression of myc protooncogenes has been implicated in the genesis of many human
tumors. Myc proteins seem to regulate diverse biological processes, but their role in …

Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only
translation factors but also pleiotropic proteins that are highly expressed in human tumors …

High-density array comparative genomic hybridization (CGH) showed amplification of
chromosome 1q22 centered on the RAB25 small GTPase, which is implicated in apical …

Synonymous codons encode the same amino acid, but differ in other biophysical properties.
The evolutionary selection of codons whose properties are optimal for a cell generates the …

In order to determine the global effects of oncogenic Ras and Akt signaling pathways on
translational efficiencies, we compared the gene expression profiles of total cellular mRNA …

Evolutionarily conserved in eukaryotes, formin homology (FH) proteins, or formins, exert
their effects on the actin and microtubule (MT) networks during meiosis, mitosis, the …