Mechanisms contributing to the pathogenesis of myocardial ischemia-reperfusion (I/R) injury
are complex and multifactorial. Many strategies have been developed to ameliorate …

Oxidative stress and apoptosis play a key role in the pathogenesis of sepsis‐associated
acute kidney injury (AKI). Dexmedetomidine (DEX) may present renal protective effects in …

Dexmedetomidine is a highly selective α 2-adrenergic agonist with analgesic and sedative
properties. In the United States, the Food and Drug Administration approved the use of the …

Background Transient global cerebral ischemia/reperfusion (I/R) is a major perioperative
complication, and diabetes increases the response of oxidative stress and inflammation …

Objective. The present study was designed to determine whether dexmedetomidine (DEX)
exerts cardioprotection against myocardial I/R injury in diabetic hearts and the mechanisms …

Background Reperfusion of ischemic tissue has adverse impact on the myocardium.
Dexmedetomidine (Dex) is a α2-adrenergic receptor (α2-AR) agonist with sedative and …

Purpose: To determine whether dexmedetomidine (DEX) could attenuate acute kidney injury
(AKI) induced by ischemia/reperfusion (I/R) in streptozotocin (STZ)-induced diabetic rats …

Baicalein is an active component of Scutellaria baicalensis Georgi, which has traditionally
been used to treat cardiovascular diseases in China. In this study, we investigated if …

Background Diabetic patients are susceptible to renal ischemia-reperfusion injury, which
leads to perioperative complications. Activation of NOD-like receptor protein 3 (NLRP3) …

Aims Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor
agonist, has anti-apoptotic, anti-inflammatory, and anti-oxidative stress effects in diabetes …