When the production of reactive oxygen species (ROS) is overloaded surpassing the
capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage …

Background Within cells, there is a narrow concentration threshold that governs whether
reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of …

Uncontrolled fibrosis in organs like heart, kidney, liver and lung is detrimental and may lead
to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders …

The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

Development of molecular probes for the detection of reactive oxygen and nitrogen species
(RONS) is important for the pathology and diagnosis of diseases. Although an abnormally …

Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic
pulmonary fibrosis (IPF), are composed of fibrogenic myofibroblasts. Autophagy has been …

Airway remodelling with subepithelial fibrosis, which abolishes the physiological functions of
the bronchial wall, is a major issue in bronchial asthma. Human bronchial fibroblasts (HBFs) …

The signaling pathways activated by Wnt ligands are related to a wide range of critical cell
functions, such as cell division, migration, and synaptogenesis. Here, we summarize …

Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …

Objectives We have previously described the antifibrotic role of the soluble guanylate
cyclase (sGC). The mode of action, however, remained elusive. In the present study, we …