Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

KD Alex, EA Pehek - Pharmacology & therapeutics, 2007 - Elsevier
The neurotransmitter dopamine (DA) has a long association with normal functions such as
motor control, cognition, and reward, as well as a number of syndromes including drug …

Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications

P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

[HTML][HTML] Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice

P Xu, Y He, X Cao, L Valencia-Torres, X Yan, K Saito… - Biological …, 2017 - Elsevier
Background Neural networks that regulate binge eating remain to be identified, and effective
treatments for binge eating are limited. Methods We combined neuroanatomic …

New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders

G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies

V Di Matteo, G Di Giovanni, M Pierucci… - Progress in brain …, 2008 - Elsevier
In this review, the functional interactions between serotonin (5-HT) and dopamine (DA)
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …

The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control

GA Higgins, LB Silenieks, A Roßmann… - …, 2012 - nature.com
Abstract Lorcaserin ((1R)-8-chloro-1-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine HCl) is
a selective 5-HT 2C receptor agonist with clinical efficacy in phase-III obesity trials. Based on …

Role of serotonin in central dopamine dysfunction

G Di Giovanni, E Esposito… - CNS neuroscience & …, 2010 - Wiley Online Library
The interaction between serotonin (5‐HT) and dopamine (DA)‐containing neurons in the
brain is a research topic that has raised the interest of many scientists working in the field of …

Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders

GA Higgins, PJ Fletcher - ACS chemical neuroscience, 2015 - ACS Publications
The neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) has long been associated with
the control of a variety of motivated behaviors, including feeding. Much of the evidence …

From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists

GA Higgins, EM Sellers, PJ Fletcher - Trends in pharmacological sciences, 2013 - cell.com
The recent US Food and Drug Administration (FDA) approval of the serotonin (5-
hydroxytryptamine, 5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity …

Presynaptic control of serotonin on striatal dopamine function

S Navailles, P De Deurwaerdère - Psychopharmacology, 2011 - Springer
Rationale The influences of the serotonergic system on dopamine (DA) neuron activity have
received considerable attention during the last three decades due to the real opportunity to …